Systematic Analysis of 0.9% NaCl Intervention in Acute and Chronic Wound Healing: Orem's Self-Care Perspective
Abstract
Wound care is an integral part of nursing practice aimed at accelerating the healing process, preventing infection-related complications, and improving patients’ quality of life. A 0.9% NaCl solution, or normal saline, is widely used as a wound-cleaning agent due to its isotonic properties that do not damage healthy tissue. Although its use is very common in clinical practice, the effectiveness of this solution in accelerating the healing of acute and chronic wounds remains a topic of debate in the scientific literature. This study aims to systematically review empirical evidence regarding the effectiveness of 0.9% NaCl solution in the wound healing process and to evaluate its relevance to Orem’s Self-Care Theory within the context of nursing interventions. This review employed a systematic literature review method by searching literature from various leading academic databases, using strict inclusion criteria to ensure the relevance and quality of the studies. The synthesis results indicate that 0.9% NaCl solution is effective in reducing the risk of infection, supporting granulation tissue growth, and can be applied independently by patients with educational support from nurses. The self-care approach in the use of this solution has been shown to enhance patient participation in wound care, particularly within the supportive-educative nursing system.These findings contribute significantly to evidence-based nursing practice and expand the application of nursing theory in simple, safe, and affordable interventions to support optimal wound healing.
Keywords: Normal saline (0.9% NaCl), wound healing, Orem’s Self-Care Theory
References
Aravindakshan, V. N., Arun, V. A., Roshni, T. S., & Anjali, V. A. (2020). A comparative study on the wound healing effectiveness of with normal saline and ionized nano-crystalline silver dressing among chronic diabetic foot ulcer patients. International Surgery Journal, 7(12), 3935. https://doi.org/10.18203/2349-2902.isj20204931
Astika, A., Sulistiowati, N., & Widyastuti, N. (2025). Efektivitas perawatan luka menggunakan NaCl 0,9% pada NY.P post partum di wilayah kerja puskesmas Petang I. Jurnal Ilmiah Kebidanan Indonesia, 13(1), 112–118.
Beula, J. (2014). Effectiveness of normal saline in healing of episiotomy wound among postnatal mothers at Government Hospital For Women & Children, Chennai.
Fernandes, S., Silva, A., Barbas, L., & Ferreira, R. (2020). Theoretical Contributions from Orem to Self-care in Rehabilitation Nursing. Gerontechnology, 163–173.
Gomaa, R., Farrag, R., Hashem, S. A. E. R. H., & Mohamed, R. (2019). Effectiveness of Betadine versus Normal Saline Dressing on Episiotomy Wound Healing. Egyptian Journal of Health Care, 10(3), 193–206.
Haddaway, N. R., Page, M. J., & Pritchard, C. C. (2022). Making literature reviews more reliable through application of lessons from systematic reviews. Nature Ecology & Evolution, 6, 327–335.
Handayani, H., Widiyanto, A., & Pratidina, Y. (2022). Waterproof dressing combined with sodium chloride to accelerate the healing of post-caesarean section wounds. Jurnal Ilmiah Keperawatan Indonesia, 10(1), 58–64.
Hartweg, D., & Metcalfe, S. (2021). Orem’s Self-Care Deficit Nursing Theory: Relevance and Need for Refinement. Nursing Science Quarterly, 35(1), 70–76.
Isik, E., & Fredland, N. M. (2021). Orem’s Self-Care Deficit Nursing Theory to Improve Children’s Self-Care: An Integrative Review. The Journal of School Nursing, 39(1).
Kalkan, N., & Karadag, M. (2024). Orem’s Self-Care Deficit Nursing Theory with Persons with Peripheral Artery Disease: A Mixed Method Study. Nursing Science Quarterly, 38, 55–66.
Kaur, S., Agnihotri, M., & Stephen, S. (2016). A Randomized, Controlled Trial to Assess the Effect of Topical Insulin Versus Normal Saline in Pressure Ulcer Healing. Ostomy/Wound Management, 62, 16–23.
Khalil, H., Peters, M. D., Tricco, A. C., Pollock, D., Alexander, L., & Munn, Z. (2020). Conducting high quality scoping reviews—Challenges and solutions. Journal of Clinical Epidemiology, 130, 156–160.
Kindel, M. E., Jung, W., Witt, R. R., Costa, I. G., Lazzari, D. D., & Carballo, K. B. (2020). Self-care of chronic wounds in the household environment: an analysis from the perspective of Dorothea Orem. Ciência, Cuidado e Saúde, 19. https://doi.org/10.4025/cienccuidsaude.v19i0.5039
Kunthikarn, R. (2023). Effect of normal saline in different concentration on soft tissue wound healing. Biomedical Journal of Scientific & Technical Research, 42(1), 32567–32572.
Lim, J. K., Saliba, L., Smith, M. J., Mctavish, J., Raine, C., & Curtin, P. (2000). The British Association of Plastic Surgeons Article no. BJPS. In British Journal of Plastic" Surgery (Vol. 53).
Liu, C., Zhang, X., Liu, X., Li, X., Chen, Y., Xiao, G., & Jiang, M. (2020). Application of Orem’s self-care theory in the nursing of patients after craniocerebral tumor surgery and its impacts on their self-care ability and mental state. Int J Clin Exp Med, 13(10), 8000–8006.
Melo, L. H. de A., Bernardo, T. H. L., Macedo, J. K. S. dos S., Francisco, L. C. F. de L., & Barros, A. C. (2020). Application of Orem’s theory on wounds: an integrative review. ESTIMA, Brazilian Journal of Enterostomal Therapy. https://doi.org/10.30886/estima.v18.821_in
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I. , H. T. C., & Mulrow, C. D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372.
Purnomo, S., Dwiningsih, S., & Prayitno, A. (2013). Penyembuhan Luka Menggunakan NaCl 0,9% Dan Hydrogel Pada Ulkus Diabetes Mellitus di RSU Kota Semarang. Jurnal Riset Kesehatan, 2(3). https://doi.org/10.31983/jrk.v2i3.384
Raditya, I., Ridia, K., Aryana, I., Fatmawati, N., & Suyasa, I. (2023). Differences in Decreasing Bacteria Colonization Wound Irrigation using 0.9% Nacl Compared with Wound Irrigation using Active Ingredients Polyhexanide 0.1% and 0.1% Betaine in Open Fractures of Long Bone. Open Access Macedonian Journal of Medical Sciences, 11, 514–518.
Rahayu, S. (2024). Wound Treatment with Moist Dressing Technique Using Nacl 0.9% And Garamysin On The Number Of Bacterial Colonies. In Enrichment: Journal of Multidisciplinary Research and Development (Vol. 2, Issue 8). https://doi.org/10.55324/enrichment.v2i8.213
Rahayu, U. M., Kholis, ;, & Huda, K. (2023). NURSING CARE FOR GRADE II DIABETIC ULCUS. Journal of Applied Health Management and Technology, 5(4). http://ejournal.poltekkes-smg.ac.id/ojs/index.php/JAHMT
Rezki, D. A., Firmansyah, I., Darussalam, D., Yusuf, S., Sovira, N., & Bakhtiar, B. (2023). The effectiveness of Lactobacillus reuteri on serum bilirubin levels in neonatal hyperbilirubinemia with phototherapy. Paediatrica Indonesiana, 63(4), 219–225. https://doi.org/10.14238/pi63.4.2023.219-25
Santos, E. I., Alves, L. F., & Pereira, M. F. (2022). Quality assessment and risk of bias in integrative reviews: A methodological study. Revista Brasileira de Enfermagem.
Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., & Stewart, L. A. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: Elaboration and explanation. BMJ, 349(g7647).
Suriani, S., Syaharuddin, S., & Asrifan, A. (2023). Application of wound cleansing using 0.9%

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